Effect of ethylthiosulfаnylate in combination with vitamin E on certain biochemical blood parameters and hematological indicators in rats under the influence of Cr(VI)

The aim of our study was to investigate the effect ethylthiosulfаnylate, a representative class thiosulfonate compounds, in combination with vitamin E on certain biochemical blood parameters, hematological indicators and total Chromium content liver rats exposed Cr(VI). Laboratory were divided into 8 groups 5 animals each. Animals group I (intact control) injected daily intraperitoneally 150 μl physiological saline solution for 7 days. Rats III/IV received intraperitoneal administration K2Cr2O7 (diluted at dose 2.5 mg Cr(VI)/kg) 7/14 II experimental intragastrically 1000 sunflower oil 14 V/VI administrated an (20 mg/kg)/vitamin mg/kg) ethylthiosulfаnylate (100 VII/VIII days, after which 7-day/14-day period performed. Exposure Cr(VI) led decrease number erythrocytes, leukocytes, hemoglobin, phospholipids, protein against background accumulation lipids, mono- diglycerides, non-esterified fatty acids, creatinine rats. concentration significantly increased combined contributed partial compensation Cr(VI)-induced disturbances leukocytes proteins, acids Vitamin pretreatment also reduction percentage